The mutant problem has gotten out of control and SHIELD is pressured to respond quickly and decisively. The only answer is to restart the Sentinel program, but will this ultimately lead to the doom of everyone on Earth? When no one on Earth is capable of stopping this threat, the Guardians of the Galaxy must step. With the help of Beta Ray Bill, the Guardians attack. But the Sentinels are not SHIELD’s only deterrent. Agent Venom and Spider-Woman have joined the fight, for with there can only be one winner.